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Lisinopril Side Effects

In Summary
Commonly reported side effects of lisinopril include: dizziness, hypotension, hyperkalemia, increased blood urea nitrogen, and increased serum creatinine. Other side effects include: headache. See below for a comprehensive list of adverse effects.

For the Consumer
Applies to lisinopril: oral solution, oral tablet

Warning
Oral route (Tablet; Solution)

Discontinue lisinopril as soon as possible when pregnancy is detected, as drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Side effects requiring immediate medical attention
Along with its needed effects, lisinopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lisinopril:

More common

Blurred vision
cloudy urine
confusion
decrease in urine output or decrease in urine-concentrating ability
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
sweating
unusual tiredness or weakness
Less common

Abdominal or stomach pain
body aches or pain
chest pain
chills
common cold
cough
diarrhea
difficulty breathing
ear congestion
fever
headache
loss of voice
nasal congestion
nausea
runny nose
sneezing
sore throat
vomiting
Rare

Arm, back, or jaw pain
chest discomfort, tightness, or heaviness
fast or irregular heartbeat
general feeling of discomfort or illness
joint pain
loss of appetite
muscle aches and pains
shivering
trouble sleeping

Side effects not requiring immediate medical attention
Some side effects of lisinopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Decreased interest in sexual intercourse
inability to have or keep an erection
lack or loss of strength
loss in sexual ability, desire, drive, or performance
rash
Rare

Acid or sour stomach
belching
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
feeling of constant movement of self or surroundings
heartburn
indigestion
muscle cramps
sensation of spinning
stomach discomfort or upset
swelling
For Healthcare Professionals
Applies to lisinopril: oral solution, oral tablet

Cardiovascular
Very common (10% or more): Hypotension (11%)

Common (1% to 10%): Chest pain, angina pectoris, orthostatic hypotension, palpitations

Uncommon (0.1% to 1%): Angioneurotic edema, myocardial infarction or cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon

Hypotension is most likely in patients who are sodium and intravascular volume depleted. In large studies, patients have reported "heart pounding" and chest pain, although the relationship to lisinopril is questionable.

Renal
Common (1% to 10%): Creatinine increased (10%)

Very rare (less than 0.01%): Renal insufficiency

Nervous system
Very common (10% or more): Dizziness (19%)

Common (1% to 10%): Headache, syncope

Uncommon (0.1% to 1%): Paresthesias

Respiratory
Common (1% to 10%): Creatinine increased (10%)

Uncommon (0.1% to 1%): Rhinitis

Very rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia

A study has revealed a significantly higher incidence of discontinuation of angiotensin converting enzyme inhibitor therapy due to cough among black patients compared with nonblack patients (9.6% vs. 2.4%).

Metabolic
Common (1% to 10%): Hyperkalemia

Frequency not reported: Gout, hypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulin

Gastrointestinal
Common (1% to 10%): Diarrhea, nausea, vomiting

Frequency not reported: Pancreatitis, constipation, flatulence, dry mouth, taste disturbance

Hypersensitivity
Uncommon (0.1% to 1%): Angioedema

Dermatologic
Uncommon (0.1% to 1%): Rash, pruritus, erythema

Rare (0.01% to 0.1%): Alopecia, urticaria, psoriasis, hypersensitivity/angioedema, angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx

Very rare (less than 0.01%): Sweating, skin lesions, skin infections, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, cutaneous pseudolymphoma

Frequency not reported: Photosensitivity, flushing, diaphoresis

Hematologic
Very rare (less than 0.01%): Bone marrow depression, hemolytic anemia, leukopenia/neutropenia, thrombocytopenia, decreases in hemoglobin, decreases in hematocrit

Psychiatric
Rare (0.01% to 0.1%): Memory impairment, confusion, somnolence, irritability, nervousness, hallucinations

Very rare (less than 0.01%): Mania

Hepatic
Common (1% to 10%): Creatinine increased

Very rare (less than 0.01%): Cholestatic jaundice that progresses to fulminant hepatic necrosis and sometimes death (discontinue of therapy if jaundice or markedly elevated hepatic serum enzymes develop)

Endocrine
Very rare (less than 0.01%): Diabetes, syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Other
Common (1% to 10%): Cough

Frequency not reported: Fatigue, asthenia, orthostatic effects, tinnitus, olfactory disturbance

Genitourinary
Uncommon (0.1% to 1%): Impotence

Rare (less than 0.1%): Gynecomastia

Frequency not reported: Proteinuria


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